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National Information Center on Health Services Research and Health Care Technology (NICHSR)


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Brown ArrowEvidence-Based Practice and Health Technology Assessment

Evidence-Based Practice: "A way of providing health care that is guided by a thoughtful integration of the best available scientific knowledge with clinical expertise. This approach allows the practitioner to critically assess research data, clinical guidelines, and other information resources in order to correctly identify the clinical problem, apply the most high-quality intervention, and re-evaluate the outcome for future improvement." 2009 Medical Subject Headings (MeSH).

Health technology assessment (HTA): "The systematic evaluation of properties, effects, and/or impacts of health care technology. It may address the direct, intended consequences of technologies as well as their indirect, unintended consequences. Its main purpose is to inform technology-related policymaking in health care. HTA is conducted by interdisciplinary groups using explicit analytical frameworks drawing from a variety of methods." Goodman, Clifford S. HTA 101: Introduction to Health Technology Assessment, 2014.

Additional information related to Evidence-Based Practice/Health Technology Assessment may be found in the Comparative Effectiveness Research (CER) Main Topic.


  • HSRR (Health Services and Sciences Research Resources) Details

    HSRR is a searchable database of information about research datasets, instruments/indices and software employed in Health Services Research, the Behavioral and Social Sciences and Public Health. The database includes brief descriptions of research resources and links to PubMed.

  • PubMed Clinical Queries Details

    A searching tool based on the work of Haynes, et al, to filter results via a series of evidence filters.




  • AHRQ Search for Research Summaries, Reviews and Reports Details

    Clinician guides from The Agency for Healthcare Research and Quality (AHRQ) Effective Health Care Program.

  • CPG Infobase: Clinical Practice Guidelines Database (CPGs) Details

    Clinical practice guidelines produced or endorsed in Canada.

  • Cochrane Collaboration Evidence Reviews Details

    Cochrane Reviews are published in The Cochrane Library - an online collection of databases that brings together in one place rigorous and up-to-date research on the effectiveness of healthcare treatments and interventions, as well as methodology and diagnostic tests.

  • ECRI Guidelines Trust™ Details

    This searchable guidelines portal provides summaries of practice guidelines. Free registration is required to access the portal.

  • EPC Evidence Reports Details

    AHRQ is developing scientific information for other agencies and organizations on which to base clinical guidelines, performance measures, and other quality improvement tools. Contractor institutions review all relevant scientific literature on assigned clinical care topics and produce evidence reports and technology assessments, conduct research on methodologies and the effectiveness of their implementation, and participate in technical assistance activities.

  • Evidence-Based Practices Resource Center Details

    The Center aims to provide communities, clinicians, policy-makers and others in the field with the information and tools they need to incorporate evidence-based practices into their communities or clinical settings. Site contains a collection of scientifically-based resources for a broad range of audiences, including Treatment Improvement Protocols, toolkits, resource guides, clinical practice guidelines, and other science-based resources.

  • Knowledge Translation (KT+) Details

    KT+ provides access to articles on the current evidence on knowledge translation including articles on quality improvement, continuing medical education, computerized clinical decision support, health services research and patient adherence. Its purpose is to inform those working in the knowledge translation area of current research as it is published.

  • MedGen: Summary of Professional Guidelines Details

    Professional practice guidelines, position statements, and recommendations relevant to a disorder, gene, or variant.

  • Methodology: Evidence-based Reports Details

    AHRQ's Evidence-based Practice Centers have developed methodologies for conducting systematic reviews.

  • Rethinking Clinical Trials: A Living Textbook of Pragmatic Clinical Trials Details

    Designed to help guide the process of creating practical clinical trials, this online wiki-based textbook is designed to assist health services researchers and clinicians in creating an appropriate clinical trial design.

  • Strings Attached: CADTH's Database Search Filters Details

    Included are search filters for Pubmed, OVID Medline, Embase, PSYCInfo filters on: Systematic Reviews/Meta-Analysis/Health Technology Assessment, Randomized Controlled Trials, Guidelines, Economic Evaluations/Cost/Economic Models, Health Utilities/Quality of Life, Narrow Economic filter.




  • AHRQ Conference Grants (R13) Details

    HRQ seeks to support conferences that help to further its mission to produce evidence to make health care safer, higher quality, more accessible, equitable and affordable, and to work with HHS and other partners to make sure that the evidence is understood and used

  • APTR-AHRQ Preventive Medicine Residency Rotations Details

    The Association for Prevention Teaching and Research (APTR) offers field placements for preventive medicine residents and primary care residents with the U.S. Preventive Services Task Force (USPSTF) Program, based at the Agency for Healthcare Research and Quality (AHRQ). The clinical preventive medicine rotation at AHRQ gives Preventive Medicine and Primary Care residents an in-depth experience in the process of developing evidence-based recommendations.

  • Practice-Based Research for Implementing Scalable Evidence-Based Prevention Interventions in Primary Care Settings (R01 Clinical Trial Optional) Details

    The purpose of this Funding Opportunity Announcement (FOA) is to encourage practice-based research aimed at testing the effectiveness of developmentally-focused theory-based efficacious prevention interventions which may impact mental health outcomes, including suicide behaviors and serious mental illness. The research should test prevention approaches that are both scalable and sustainable for implementation in pediatric-serving primary care settings, with an emphasis on populations experiencing mental health disparities.

  • Practice-Based Research for Implementing Scalable Evidence-Based Prevention Interventions in Primary Care Settings (R34 Clinical Trial Required) Details

    The purpose of this Funding Opportunity Announcement (FOA) is to encourage practice-based research aimed at refining and pilot testing developmentally-focused, theory-based efficacious prevention interventions that may impact mental health outcomes, including suicide behaviors and serious mental illness. The research should test prevention approaches that are both scalable and sustainable for implementation in pediatric-serving primary care settings, with an emphasis on populations experiencing mental health disparities.




  • Campbell Collaboration Library of Systematic Reviews Details

    Systematic reviews in education, crime and justice, and social welfare.

  • Canadian Agency for Drugs and Technologies in Health Details

    National body that provides Canada's federal, provincial and territorial health care decision makers with credible, impartial advice and evidence-based information about the effectiveness and efficiency of drugs and other health technologies. It was formerly known as the Canadian Coordinating Office for Health Technology Assessment (CCOHTA)

  • Center for Evidence-based Policy Details

    The Center is a national leader in evidence-based decision making and policy design, working with federal, state and local policymakers in more than 20 states to use high-quality evidence to guide decisions, maximize resources and improve health outcomes.

  • Centre for Evidence-Based Medicine Details

    Aims to develop, teach and promote evidence-based health care and provide support and resources to doctors and health care professionals to help maintain the highest standards of medicine.

  • Centre for Reviews and Dissemination Details

    Part of the National Institute for Health Research, CRD undertakes high quality systematic reviews that evaluate the effects of health and social care interventions and the delivery and organisation of health care.

  • Cochrane Collaboration Details

    Improving healthcare decision-making globally, through systematic reviews of the effects of healthcare interventions.

  • ECRI Institute Details

    An independent, nonprofit health services research agency that works to improve the quality, safety, and cost-effectiveness of patient care. Provides a wide range of services dealing with healthcare technology, including research, evaluation, assessment, publications, and databases. Other areas of interest include: healthcare risk and quality management, and healthcare environmental management.

  • EUnetHTA (European Network for Health Technology Assessment) Details

    Focusing on scientific cooperation in HTA in Europe, thirty four government appointed organisations from the EU Member States, Accession Countries and EEA work together to help developing reliable, timely, transparent and transferable information to contribute to HTAs in European countries. The EUnetHTA Joint Action builds on the achievements of a number of the previous European initiatives including the EUnetHTA Project (2006-2008) and the Pharmaceutical Forum (on relative effectiveness).

  • Effective Health Care Program Details

    The Effective Health Care Program is dedicated to facilitating decision making by providing findings from high-quality research in formats for different audiences.

  • Equator Network Details

    This initiative seeks to improve the reliability and value of published health research literature by promoting transparent and accurate reporting and wider use of robust reporting guidelines. The website contains a blog, a library for health research reporting, a toolkit to promote accurate publication of health research, and upcoming and past events and classes.

  • Evidence-based Practice Centers (EPC) Program Details

    Under the Evidence-based Practice Centers (EPC) Program of five-year contracts are awarded to institutions in the United States and Canada to serve as EPCs. The EPCs review all relevant scientific literature on clinical, behavioral, and organization and financing topics to produce evidence reports and technology assessments. These reports are used for informing and developing coverage decisions, quality measures, educational materials and tools, guidelines, and research agendas. The EPCs also conduct research on methodology of systematic reviews.

  • Evidence-based Practice Centers (EPCs) Details

    Evidence-based Practice Centers (EPCs) are top-ranking institutions where research reviews for the AHRQ Effective Health Care Program are made. EPCs are housed at 15 of the nation's top medical schools, universities, or medical centers. Access research reviews, original research reports, and summary guides.

  • Evidence-based Synthesis Program Details

    The Evidence-based Synthesis Program (ESP) was established to provide timely and accurate syntheses of targeted health care topics of particular importance to VA managers and policy makers and to disseminate these reports broadly throughout VA. Access published reports as well as reports in progress.

  • EvidenceNOW: Advancing Heart Health in Primary Care Details

    A grant initiative dedicated to helping small- and medium-sized primary care practices across the country use the latest evidence to improve heart health.

  • Health Information Research Unit, HIRU, McMaster University Details

    Conducts research in the field of health information science and is dedicated to the generation of new knowledge about the nature of health and clinical information problems, the development of new information resources to support evidence-based health care, and the evaluation of various innovations in overcoming health care information problems.

  • Health Technology Assessment Details

    The primary purpose of HTA is to ensure medical treatments and services paid for with state health care dollars are safe and proven to work. HTA serves as a resource for state agencies purchasing health care. HTA contracts for scientific, evidence-based reports about whether certain medical devices, procedures, and tests are safe and work as promoted. An independent clinical committee of health care practitioners then uses the reports to determine if programs should pay for the medical device, procedure, or test.

  • Health Technology Assessment International (HTAi) Details

    Focuses uniquely on health technology assessment (HTA) and provides the key forum for all those from the worlds of health care, academia and business interested in the science, development and application of HTA. Health technology assessment (HTA) offers "supporting evidence based decision making in health care policy and practice".

  • Healthcare Delivery Research Program Details

    NCI's work related to quality of care research and the translation of this research into practice is available through the links on this website.

  • Institute for Clinical Systems Improvement Details

    Non-profit organization that brings together diverse groups to transform the health care system so that it delivers patient-centered and value-driven care.

  • Institute of Health Economics Details

    The IHE strives to assist decision makers in health policy and practice with the results from economic evaluations, costing and cost-effectiveness analyses, and with syntheses of findings from research in health technology assessment.

  • International Society for Pharmacoeconomics and Outcomes Research (ISPOR) Details

    ISPOR promotes the science of pharmacoeconomics (health economics) and outcomes research (the scientific discipline that evaluates the effect of health care interventions on patient well-being including clinical outcomes, economic outcomes, and patient-reported outcomes) and facilitates the translation of this research into useful information for healthcare decision-makers to ensure that society allocates scarce health care resources wisely, fairly and efficiently. ISPOR embraces all health technology assessors, government health technology regulators & payers of health care including governments, insurers, and other health care payers who use health care outcomes research information in their decisions.

  • International Society for Quality in Health Care (ISQua) Details

    International membership organization including leading quality health care providers and agencies in just under 70 countries. The ISQua Secretariat is located in Australia.

  • Joanna Briggs Institute Details

    Based within the University of Adelaide, Australia, the JBI promotes the synthesis, transfer and utilization of evidence by identifying effective healthcare practices to assist in the improvement of healthcare outcomes globally.

  • Medical Technology and Practice Patterns Institute (MTPPI) Details

    A nonprofit organization established in 1986 to conduct research on the clinical, economic, and social implications of new and emerging health care technologies.

  • NExT - Nursing Experts: Translating the Evidence Details

    The NExT project website is a tool for learning about evidence based public health practice and a portal to evidence based practice resources. The site was developed with a primary audience of public health nurses but will be of interest to everyone interested in learning more about evidence based public health. The site includes a free online course which offers 3 free CEUs to nurses.

  • NHS Health Technology Assessment Programme Details

    The HTA programme is part of the National Institute for Health Research (NIHR). It produces independent research information about the effectiveness, costs and broader impact of healthcare treatments and tests for those who plan, provide or receive care in the NHS.

  • National Institute for Health and Clinical Excellence (NICE) Details

    NICE produces guidance in health technologies with guidance on the use of new and existing medicines, treatments and procedures within the NHS clinical practice; and guidance on the appropriate treatment and care of people with specific diseases and conditions within the NHS.

  • National Institutes of Health Health Care Systems Research Collaboratory Details

    Composed of seven core working groups, the NIH Collaboratory's goal is to ensure that healthcare providers and patients can make decisions based on the best available clinical evidence.

  • National Quality Forum (NQF) Details

    Not-for-profit membership organization created to develop and implement a national strategy for health care quality measurement and reporting.

  • Quality Enhancement Research Initiative (QUERI) Details

    Works to improve the quality of healthcare for veterans by implementing research findings into routine clinical practice. The QUERI centers focus on nine high-risk and/or highly prevalent diseases or conditions among veterans.

  • SNOMED International Details

    Formerly the International Health Terminology Standards Development Organisation (IHTSDO), this organization is a not-for-profit association that develops and promotes use of SNOMED CT to support safe and effective health information exchange. SNOMED CT is a clinical terminology and is considered to be the most comprehensive, multilingual healthcare terminology in the world.

  • Swedish Council on Technology Assessment in Health Care (SBU) Details

    SBU presents the scientific evidence on the benefits, risks, and costs associated with different interventions. SBU identifies methods that offer the greatest benefits and the least risk, focusing on the most efficient ways to allocate healthcare resources. However, SBU also identifies methods currently in use that provide no benefits, have not been assessed, or are not cost effective.

  • Technology Assessment Program Details

    This program provides technology assessments for the Centers for Medicare & Medicaid Services (CMS). AHRQ's technology assessment program uses state-of-the-art methodologies for assessing the clinical utility of medical interventions. Technology assessments are based on a systematic review of the literature, along with appropriate qualitative and quantitative methods of synthesizing data from multiple studies.