Brown ArrowComparative Effectiveness Research (CER)

Comparative effectiveness research is the conduct and synthesis of systematic research comparing different interventions and strategies to prevent, diagnose, treat and monitor health conditions. The purpose of this research is to inform patients, providers, and decision-makers, responding to their expressed needs, about which interventions are most effective for which patients under specific circumstances. To provide this information, comparative effectiveness research must assess a comprehensive array of health-related outcomes for diverse patient populations…[Internet.] Federal Coordinating Council for Comparative Effectiveness Research, definition; [cited 28 July 2010].

Access specialized searches for published research—PubMed, and research still in progress, HSRProj, and ClinicalTrials.gov—to help inform investigations of comparative effectiveness.

Additional information related to CER may be found in the Evidence-Based Practice/Health Technology Assessment Main Topic.



  • Agency for Healthcare Research and Quality's Process for Awarding Recovery Act Funds and Disseminating Results (2012) Details

    According to AHRQ officials, the agency plans to disseminate the results of Recovery Act-funded CER using a range of existing mechanisms. These mechanisms include written products, training programs, social media tools, and AHRQ's website. AHRQ is also developing additional strategies to disseminate CER results. AHRQ awarded four contracts using Recovery Act funds totaling approximately $42.3 million to promote innovative approaches for disseminating CER results. A variety of efforts are conducted under these contracts, including efforts to educate clinicians and develop regional dissemination offices.

  • H.R. 2502 - Comparative Effectiveness Research Act of 2009 Details

    On May 19, 2009, Rep. Kurt Schrader (D-OH), joined by 11 co-sponsors, introduced H.R. 2502, "The Comparative Effectiveness Research Act of 2009." This legislation would establish a private, non-profit organization, the Health Care Comparative Effectiveness Research Institute, to conduct research evaluating and comparing the implications and outcomes of two or more health care therapies in treating a particular medical condition.

  • HHS Research Awards: Use of Recovery Act and Patient Protection and Affordable Care Act Funds for Comparative Effectiveness Research Details

    The 2011 Department of Defense and Full-Year Continuing Appropriations Act, required GAO to report on HHS's funding of CER under the Recovery Act and PPACA (Patient Protection and Affordable Care Act). This June 2011 report includes information on the expenditures HHS has made using these funds, the entities that have received such funding, and the purpose of the funding.

  • Patient-Centered Outcomes Research Institute (PCORI) Details

  • Public Law 111-152, Health Care and Education Reconciliation Act of 2010 Details

    Health Care and Education Reconciliation Act of 2010 - Title I: Coverage, Medicare, Medicaid, and Revenues - Subtitle A: Coverage - (Sec. 1001) Amends Internal Revenue Code provisions added by the Patient Protection and Affordable Care Act (PPACA) to revise the formula for calculating the refundable tax credit for premium assistance for coverage under a qualified health plan by establishing a sliding scale from the initial to the final premium percentage for individuals and families with household incomes up to 400% of the federal poverty line. Requires adjustments, after 2014 and after 2018, of the initial and final premium percentages to reflect the excess (if any) of the rate of premium growth over the rate of growth of income and the consumer price index.

  • Public Law No: 111-148-March 23, 2010, Patient Protection and Affordable Care Act Details

    Link to the PDF of the full text of the Patient Protection and Affordable Care Act.